(-)-Epigallocatechin
gallate (EGCG)
DESCRIPTION:
Our product, EGCG is a kind of component
extracted from the Chinese green tea. It is the
mainly active and water-soluble component from
green tea, whose content is the highest in the
tea catechins. It accounts for 9-13% of green
tea in net weight. By virtue of its peculiar stereochemical
structure, EGCG possesses much stronger anti-oxidant
activities and plays an important role in preventing
from cancer and cardiovascular diseases. In addition,it
is potently used as the reversal agent of MDR
(Multidrug Resistance), which may improve the
sensitivity of the cancer cell to the chemotherapy
drug and reduce the toxicity on the heart.
Specifications:
|
Specification |
Other items* |
Color |
Application |
|
EGCG 99% |
/ |
Off-white |
Medicine, Analysis |
EGCG 98% |
/ |
Off-white |
Medicine, Analysis |
EGCG 90% |
/ |
Off-white |
Medicine, Health food、Cosmetics |
EGCG 60% |
Tea Polyphenol 99% min, Tea Catechins 80% min |
Yellow |
Health food、Cosmetics, Food |
EGCG 50% |
Tea Polyphenol 99% min, Tea Catechins 75% min |
Dark Yellow |
Health food、Food, Beverage |
EGCG 40% |
Tea Polyphenol 90% min, Tea Catechins 70% min |
Dark Yellow |
Health food、Food, Beverage |
Product Information:
| CAS
Number: |
|
989-51-5 |
| Synonym: |
|
(2R, 3R)-2-(3,4,5-Trihydroxy-phenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
3-(3,4, 5-trihydroxybenzoate),(-)-Epigallocatechin
gallate, (-)-Epigallocatechin gallate 3-O-gallate |
|
Molecular Formula: |
|
C22H18O11 |
| Molecular
Weight: |
|
458.4 |
|
Solubility: |
|
Clear colorless solution
at 5Mg/Ml in water. |
| Test
Item: |
|
Appearance, Loss on drying,
Total Ash, Assay,
Heavy Metals, Arsenic, Microbiological. |
|
Packing: |
|
Nt.W:1kg/Al drum, with
the inner plastic bag |
| Storage: |
|
Store in a cool and dry area, keep sealed and keep away from direct light |
*Caffeine is according to customer requirement
Biological effects:
(-)-Epigallocatechin gallate (egcg),
an most potent antioxidant polyphenols of green
tea, is associated with antioxidant, antitumor
and antimutagenic activities. The antioxidant
activity is at lest 100 times effective
than vitamin C and 25 timeseffective than
vitamin E at protecting cells and DNA from damage which
are believed to be linked to cancer, heart disease
and other potentially fatal illnesses. The biological
benefits of EGCG are generally attributed to their
antioxidant activity to scavenge free radical
oxygen.
EGCG is the major component of the
polyphenolic fraction of green tea. It makes up
about 10-50% of the total green tea catechins includeing
epigallocatechin gallate (EGCG), epigallocatechin
(EGC), epicatechin gallate(ECG), epicatechin(EC), gallocatechin
gallate (GCG), catechin are major catechin of
green tea catechin. The antioxidant activity increased
in the following order: EC<ECG<EGC<EGCG.
Many studies indicate EGCG plays
a role, which protects aganist free-radical DNA damage, protects
aganist the effects of ionizing radiation and
ultraviolet radiation, ;inhibits lipid peroxidation,
decreases serum cholesterol levels, LDL, VLDL and
triglycerides, interferes with the binding of cancer-causing
agents to cellular DNA, helps to neutralize dietary
carcinogens, works with enzymes and other antioxidants
in the intestine, liver and lungs to prevent the
activation of certain carcinogens before they
damage DNA. As a free radicals scavenger, EGCG combats
the effects of pollution, sunlight and smoking,
helps skin from wrinkling and aging.
Safety:
Green tea consumption of as much
as 20 cups per day has not been assoiated with
any significant side effects. Acute studies reported
the oral LD50 of EGCG in mice was 2170mg/kg bw.
Application:
Medicine, Health food, Food, Beverage,
Cosmetics and Beverage, etc.
|
