Paclitaxel is an alkaloid isolated from the pacific yew Taxus brevifolia, is one of the most effective anti-tumor agents currently used for the therapy of ovarian, breast cancers and non-small cell lung cancer.
Paclitaxel is an new antimicrotubule agent
that promotes the assembly and stabilization of microtubules, finally induces mitotic block and apoptosis of cancer cell.
Now, paclitaxel has been widely used clinically as a potent chemotherapeutic agent by exerting anti-tumor and antiangio-genic effect, it became the first-line drug for ovarian cancer without doubt.