Published date: Oct 18, 2018 Tags: EGCG Epigallocatechin gallate green tea extract
EGCG is a kind of component extracted from Chinese green tea. It is the primary active and water-soluble component of green tea, which has the highest content among the the tea catechins. It accounts for 9-13% of green tea in net weight. By virtue of its peculiar stereochemical structure, EGCG possesses much stronger anti-oxidant activities and plays an important role in preventing cancer and cardiovascular diseases. In addition, it is potent as the reversal agent of MDR (Multidrug Resistance). As such, it may improve the sensitivity of cancer cells to chemotherapy drugs and reduce toxicity on the heart.
Specifications:
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Specification |
Other items* |
Color |
Application |
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EGCG 99% |
/ |
Off-white |
Medicine, Analysis |
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EGCG 98% |
/ |
Off-white |
Medicine, Analysis |
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EGCG 95% |
/ |
Off-white |
Dietary supplement,Cosmetics,Medicine |
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EGCG 90% |
/ |
Off-white |
Dietary supplement,Cosmetics,Medicine |
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EGCG 60% |
Tea Polyphenol 99% min, Tea Catechins 80% min |
Yellow |
Health foodCosmetics, Food |
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EGCG 50% |
Tea Polyphenol 99% min, Tea Catechins 75% min |
Dark Yellow |
Health foodFood, Beverage |
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EGCG 40% |
Tea Polyphenol 90% min, Tea Catechins 70% min |
Dark Yellow |
Health foodFood, Beverage |
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CAS Number: |
989-51-5 |
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Synonym: |
(2R, 3R)-2-(3,4,5-Trihydroxy-phenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4, 5-trihydroxybenzoate),(-)-Epigallocatechin gallate, (-)-Epigallocatechin gallate 3-O-gallate |
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Molecular Structure: |
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Molecular Formula: |
C22H18O11 |
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Molecular Weight: |
458.4 |
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Solubility: |
Clear colorless solution at 5Mg/Ml in water. |
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Test Item: |
Appearance, Loss on drying, Total Ash, Assay, Heavy Metals, Arsenic, Microbiological. |
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Packing: |
Nt.W:1kg/Al drum, with the inner plastic bag |
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Storage: |
Store in a cool and dry area, keep sealed and keep away from direct light |
Biological effects
(-)-Epigallocatechin gallate (egcg), an most potent antioxidant polyphenols of green tea, is associated with antioxidant, antitumor and antimutagenic activities. The antioxidant activity is at lest 100 times effective than vitamin C and 25 timeseffective than vitamin E at protecting cells and DNA from damage which are believed to be linked to cancer, heart disease and other potentially fatal illnesses. The biological benefits of EGCG are generally attributed to their antioxidant activity to scavenge free radical oxygen.
EGCG is the major component of the polyphenolic fraction of green tea. It makes up about 10-50% of the total green tea catechins includeing epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate(ECG), epicatechin(EC), gallocatechin gallate (GCG), catechin are major catechin of green tea catechin. The antioxidant activity increased in the following order: EC
Many studies indicate EGCG plays a role, which protects aganist free-radical DNA damage, protects aganist the effects of ionizing radiation and ultraviolet radiation, ;inhibits lipid peroxidation, decreases serum cholesterol levels, LDL, VLDL and triglycerides, interferes with the binding of cancer-causing agents to cellular DNA, helps to neutralize dietary carcinogens, works with enzymes and other antioxidants in the intestine, liver and lungs to prevent the activation of certain carcinogens before they damage DNA. As a free radicals scavenger, EGCG combats the effects of pollution, sunlight and smoking, helps skin from wrinkling and aging.
Safety
Green tea consumption of as much as 20 cups per day has not been assoiated with any significant side effects. Acute studies reported the oral LD50 of EGCG in mice was 2170mg/kg bw.
Application
Medicine, Health food, Food, Beverage, Cosmetics and Beverage, etc.
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